Exclusive Services
1. Custom Synthesis
2. Medicinal Chemistry
3. Process Chemistry
4. Contract Research And Manufacturing Services (CRAMS)
1
Custom Synthesis
Pharma companies and Drug Discovery research groups require variety of small molecules, building blocks and linkers for their drug development projects. To meet this requirement, we provide custom synthesis services to our worldwide customers under strict confidentiality agreements. We cater to chemical biology and biotech companies with custom synthesis of requested target compounds with high purity in time. We have scientists with strong technical experience to deliver services on time with reliability. Our team communicates with customers on a weekly basis to update the progress, share the data, and address the issues.
We are committed to provide Certificates of Analysis (COA) to our customers including analytical data reports as requested by customer for every compound we deliver.
Design and Development of small molecules, building blocks, molecular probes
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Synthetic Route Design and Optimization
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Small and Large-Scale Chemistry Capabilities
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Custom synthesis in quantities ranging from milligrams to multi-kilogram orders
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Cost-Effectiveness and High Efficiency
2
Medicinal Chemistry
Typically, Medicinal Chemistry projects include 4 preliminary stages: 1) Design 2) Synthesis 3) Biological screening and 4) PK and PD studies. We synthesize molecules to fulfill synthesis requirements at all these stages for medicinal chemistry groups to assist in structure-activity relationship studies. Our scientific team has expertise to handle diverse chemical structure classes, which may vary from heterocycles, amino acids, carbohydrates, secondary metabolites, alkaloids, terpenoids, and polyketides.
Our services for medicinal chemistry include:
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Hit to lead optimization employing standard Structure Activity Relationship (SAR) studies
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Synthesis of libraries of compounds
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Synthesis of Reference Standards; Building Blocks; Analogues; Intermediates and specially designed Lead Molecules
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Synthesis of Biomarkers and Biological probes to study biological mechanisms
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Impurity profiling according to the customer’s requirement including structural elucidation of unknown impurities
3
Process Chemistry
We provide services in the area of Process Chemistry for the preparation of APIs, standards, and intermediates. To protect patent rights, we typically undertake non-infringing process development and optimization of a new process to the most cost-effective route by selecting reagents, solvents, reaction conditions and purifications methods and by minimizing number of operations.
Our process research Services include:
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Route selection and Process development
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Synthetic feasibility and scale up
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Process improvement and optimization
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Evaluation of scalability and Process Safety
4
Contract Research And Manufacturing Services (CRAMS)
Vallark Pharma is developing expertise to offer long term Contract Manufacturing services immediately from strategic partnerships in development, validations, Drug Master File (DMF) submission and commercial manufacturing of Active Pharmaceutical Ingredients (APIs)/advanced intermediates to APIs with a flexible business model.
Mode of Business
Vallark Pharma has a flexible business model designed to create win-win relationships with all its clients.
Contract Research (FTE – Full Time Equivalent): We dedicate chemist’s time to a project from the beginning to the end of the project. Well trained chemists in synthesis, purification, and analysis will be assigned for FTE projects. Project managers coordinate clients and chemists by conducting video conferences and communicate personally or through emails.
o efficient and well-trained chemists
o molecules synthesis from mg to multiple grams
o excellent supply chain arrangement with our chemical vendors to procure chemicals within 1-2 days time.
o competitive FTE cost based on chemistry and quantity
o full transparency with laboratory note books, analysis data and schemes
o provides regular updates to the client by email communication and by weekly meetings.
Custom Synthesis (FFS – Fee for service):
Target oriented synthesis will be achieved by group of chemists to meet timelines and is assured to provide high purity of compounds as per client’s expectations. Complete analytical data will be provided for significant intermediates and target molecules as per the request.
o Quote within 2-3 days
o excellent supply chain arrangement with our chemical vendors to procure chemicals within 1-2 days time.
o molecules synthesis from mg to multi grams
o competitive cost based on complexity of chemistry and quantity
o full transparency with laboratory note books, analysis data and schemes
o Strictly follow timelines to achieve the target synthesis. In case of any delay clearly discusses the challenges with clients.
o provides step-wise characterization data for multi-step projects